According to Deadline, the users of the social platform began to experience issues at 11:30 pm ET (04:30 GMT+1 Tuesday) as users were left unable to access the Instagram app worldwide.
Down Detector shows that users in the UK, US, South America, Australia, Japan, India and others were subjected to the outage.
Facebook did not release any statement about the outage as the cause for it is yet unknown, though the service is back and running smoothly as it was before.
Facebook and its family of apps, in May suffered a worldwide outage that lasted for 12 hours which it later blamed on a server configuration error.
On Sunday, Google Search, Gmail, YouTube, Discord, Nest, Snapchat and other apps suffered a global outage across the US and UK.
Google later blamed the outage on its Cloud service which powers it said experienced issues.